February 26, 2013

$PVCT: It's the #immune system, #stupid.

"It's the economy, stupid" is a slight variation of the phrase "The economy, stupid" which James Carville had coined as a campaign strategist of Bill Clinton's successful 1992 presidential campaign against sitting president George H. W. Bush. (Source: Wikipedia).

To understand PV-10 is to understand the relationship between chemoablation and immune-mediated signaling. It's what Craig means when he says the immune system responds in direct proportion to the degree of insult. Think of PV-10 chemoablation as the proxy for the degree of insult, which is rapid, complete and durable in the case of PV-10. Moffitt should say the same thing in its conference presentation(s) and contemporaneous peer-reviewed publication.

A good amount of work -- creative, innovative, pragmatic, historical, scientific, medical literature-based, etc. -- went and a continues to go into dosing, of historical and upcoming clinical trials, of certain indications, of pre-clinical work on newer indications.

Yes, management doesn't talk openly about dosing, nor do they talk openly about several other topics of import and value.

The thing that makes you go hmmmm... Rose Bengal has an established safety history, a short half-life in the bloodstream, and is excreted via the liver and kidneys. The half-life is measured in minutes, like 15-30 or thereabouts. The drug is gone from the body almost immediately, so there is never enough of it to kill remote (untreated) tumors like what injected (treated) tumors receive via intratumoral delivery. PV-10 is long gone before the immune system removes the untreated ones. Hmmmm...

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