March 19, 2013

$PVCT: Immunotherapy in the management of melanoma: current status

Source link here. Rose Bengal (PV-10) is detailed on page 6.

Conclusion: "New and evolving immunotherapeutic agents are yielding meaningful and promising clinical responses in patients with metastatic melanoma. Numerous clinical questions remain unanswered, including optimal dosing regimens, synergistic combination therapy, and the management of adverse effects. As research continues, consideration should be given to the development of predictive biomarkers to determine which therapy may be most appropriate. Furthermore, additional trials are needed to investigate combination therapies and drug resistance in order to maximize clinical outcomes. It should be emphasized that despite the widespread research and clinical excitement produced by these agents, their actual efficacy remains relatively poor. It is plausible that part of the reason why Food and Drug Administration approval was obtained for ipilimumab and vemurafenib resulted, in part, from a glimpse of optimism during an otherwise stagnant decade of developments in melanoma drug therapy. Finally, regardless of how effective and durable response rates appear, the economical availability of these agents in mainstream medicine likely poses the greatest impediment to their widespread use."

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