$PVCT's Process for the Synthesis of 4,5,6,7-tetrachloro-3',6'-dihydroxy-2',4',5',7'-tetraiodo-3H-spiro[isoben- zofuran-1,9'-xanthen]-3-one (Rose Bengal) and Related Xanthenes

Provectus' synthesis patent application, which essentially is a near-composition of matter one, is very important for several reasons. Among them, the concentration of rose bengal could be increased in
solution, if this was necessary and appropriate, without increasing the purity of the active pharmaceutical ingredient (because the company's new manufacturing process greatly reduces the variable level of impurities). I expect positive news on this item in 2013.